Immobilized Polysaccharide-Based Chiral Stationary Phases for HPLC
نویسندگان
چکیده
منابع مشابه
Pharmaceutical-enantiomers resolution using immobilized polysaccharide-based chiral stationary phases in supercritical fluid chromatography.
Since their introduction on the market the applicability of immobilized polysaccharide-based chiral stationary phases in high-performance liquid chromatography has been thoroughly investigated. These immobilized phases have the benefit to be applicable with a wide range of modifiers, potentially extending the application range of the polysaccharide-based stationary phases. Because an increasing...
متن کاملHplc Separation of Linezolid Enantiomers Using Polysaccharide-based Chiral Stationary Phases
Separation of the enantiomers of linezolid has been compared on derivatized cellulose and amylose chiral stationary phases (Chiracel OD and Chiralpak AD) with mixtures of hexane with 1-propanol, 2-propanol, or ethanol as mobile phases. It was found that use of a small amount of water as mobile phase additive can improve or prevent enantioseparation, depending on the column. The order of elution...
متن کاملHPLC-fluorescence method for the enantioselective analysis of propranolol in rat serum using immobilized polysaccharide-based chiral stationary phase.
A stereoselective high-performance liquid chromatographic (HPLC) method was developed and validated to determine S-(-)- and R-(+)-propranolol in rat serum. Enantiomeric resolution was achieved on cellulose tris(3,5-dimethylphenylcarbamate) immobilized onto spherical porous silica chiral stationary phase (CSP) known as Chiralpak IB. A simple analytical method was validated using a mobile phase c...
متن کاملEnantiomeric Resolution of Drugs and Metabolites in Polysaccharide- and Protein-Based Chiral Stationary Phases
Várias fases estacionárias baseadas em derivados de polissacarídeos e proteínas foram avaliadas para a resolução de alguns fármacos quirais e seus metabólitos. As fases estacionárias baseadas em polissacarídeos CHIRALCEL OD-H, CHIRALCEL OB-H, CHIRALCEL OJ, CHIRALPAK AD e CHIRALPAK AS foram avaliadas em condições de fase normal, usando hexano:2-propanol como fase móvel. Dietilamina ou ácido trif...
متن کاملReview High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases
In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polymer Journal
سال: 2006
ISSN: 0032-3896,1349-0540
DOI: 10.1295/polymj.38.91